ABSTRACT
Introduction: For diagnosis of hematological disorders there are three modalities to examine bone marrow, bone marrow aspiration cytology (BMA), bone marrow biopsy (BMB) and touch imprint cytology (BMI). BMA gives cytological picture, BMI also gives cytological picture but cells are less in number and BMB gives cytological as well as bone marrow architectural picture. BMA alone may not be sufficient to reach diagnosis therefore the present study was undertaken to compare the above three modalities. Material and methods: The present study was a prospective study done from January 2013 to December 2013. Total 51 cases, where BMA, BMI and BMB were performed on OPD and IPD patients at Dhiraj General Hospital, Vadodara were included. Complete clinical data were recorded including physical examination, complete hematological study along with other relevant investigations and proforma filled. Results: The various diseases diagnosed by BMA, BMI and BMB were megaloblastic anemia (19.6%), aplastic/ hypoplastic anemia (13.7%), iron deficiency anemia/ micronormoblastic erythroid hyperplasia (2.0%), dimorphic anemia (5.9%), idiopathic thrombocytopenic purpura (2.0%), plasma cell dyscrasias (3.9%), Myeloproliferative disorders (3.9%), leukemia (15.7%), normocellular marrow (13.7%), metastasis (15.7%) and miscellaneous (3.9%). Conclusion: BMA is found to be the superior procedure for evaluation of hematological disorders compared to BMI and BMB.
ABSTRACT
Pulmonary carcinosarcoma is an aggressive rare malignant tumor comprising a mixture of carcinoma and sarcoma components containing differentiated mesenchymal elements, such as malignant cartilage, bone, and skeletal muscle. We report a case which presented with unusual clinical features and proved cryptic until death. At autopsy, it was a stage IV lung malignancy and histopathology revealed a carcinosarcoma comprising an adenocarcinoma and an osteosarcoma with metastasis to the heart, lymph nodes, and both adrenals. To our knowledge, this is the first case of this subtype with metastasis to the heart. The present case had an unusual clinical presentation and its elusive nature towards diagnosis despite dissemination is noteworthy and unique in the literature.
ABSTRACT
A 23-year-old male presented with clinical and radiological features of left lung collapse. Fibre-optic bronchoscopy revealed a smooth globular mass almost completely occluding the left main bronchus. Needle aspiration and endobronchial biopsy from the mass revealed it to be a case of anaplastic large cell lymphoma, a subtype of non-Hodgkin's lymphoma. This report documents the rare presentation of non-Hodgkin's lymphoma as an endobronchial mass.